High-fat meals trigger bodily responses that may lead to heart disease, according to a study published in Laboratory Investigation. Researchers compared blood labs and blood cells in ten healthy men before and after each consumed one high-fat milkshake. The milkshake significantly increased total cholesterol, triglycerides, and fatty acid levels four hours after consumption. Researchers also observed changes in red blood cell structure and increased RBC-bound myeloperoxidase (MPO), an enzyme associated with oxidative stress and arterial plaque destabilization. These findings are similar to those from other studies over the years.
Benson TW, Weintraub NL, Kim HW, et al. A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome. Lab Invest. Published online March 23, 2018.